Metformin restores electrophysiology of small conductance calcium-activated potassium channels in the atrium of GK diabetic rats

Metformin restores electrophysiology of small conductance calcium-activated potassium channels in the atrium of GK diabetic rats

Abstract Background Small conductance calcium-activated potassium channels (SK channels) play a critical role in action potential repolarization in cardiomyocytes. Recently, the potential anti-arrhythmic effect of metformin in diabetic patients has been recognized, yet the underlying mechanism remai...

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Bibliographic Details
Main Authors: Xi Fu, Yilong Pan, Qian Cao, Bin Li, Shuo Wang, Hongjiao Du, Na Duan, Xiaodong Li
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cardiovascular Disorders
Subjects:
Small conductance calcium-activated potassium channel
SK channel
Metformin
Diabetes
Arrhythmia
Online Access:http://link.springer.com/article/10.1186/s12872-018-0805-5

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http://link.springer.com/article/10.1186/s12872-018-0805-5

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