Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.

The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given...

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Bibliographic Details
Main Authors: James Watson, Walter R J Taylor, Germana Bancone, Cindy S Chu, Podjanee Jittamala, Nicholas J White
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5931686?pdf=render