The clinical, immunological and genetic features of 12 Chinese patients with STAT3 mutations

The clinical, immunological and genetic features of 12 Chinese patients with STAT3 mutations

Abstract Background Loss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) is one of the causes of STAT3 hyperimmunoglobulin E (IgE) syndrome (STAT3-HIES), while gain-of-function (GOF) mutations in STAT3 lead to immune dysregulation diseases. We retrospectivel...

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Bibliographic Details
Main Authors: Li Lin, Ying Wang, Bijun Sun, Luyao Liu, Wenjing Ying, Wenjie Wang, Qinhua Zhou, Jia Hou, Haili Yao, Liyuan Hu, Jinqiao Sun, Xiaochuan Wang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Allergy, Asthma & Clinical Immunology
Subjects:
STAT3
Hyperimmunoglobulin E syndrome
HIES
Primary immunodeficiency disease
STAT3 deficiency
Online Access:http://link.springer.com/article/10.1186/s13223-020-00462-w

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http://link.springer.com/article/10.1186/s13223-020-00462-w

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