Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORα) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock

Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORα) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock

The transcription factor Related Orphan Receptor Alpha (RORα) plays an important role in regulating circadian rhythm, inflammation, metabolism and cellular development. Herein we show that in the absence of functional RORα in mice there is reduced susceptibility to LPS-induced endotoxic shock, with...

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Bibliographic Details
Main Authors: Emily Hams, Joseph Roberts, Rachel Bermingham, Padraic G. Fallon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
RORA
macrophage
inflammation
LPS
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.647329/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.647329/full

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