The efficacy of the cyclin-dependent kinase 4/6 inhibitor in endometrial cancer.

The efficacy of the cyclin-dependent kinase 4/6 inhibitor in endometrial cancer.

BACKGROUND:PD-0332991, the selective cyclin-dependent kinase 4/6 inhibitor palbociclib, causes cell cycle arrest by inhibiting phosphorylation of retinoblastoma (Rb) protein. The aim of this study was to evaluate the therapeutic potential of PD-0332991 in endometrial cancer. METHODS AND FINDINGS:Fou...

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Bibliographic Details
Main Authors: Tomohito Tanaka, Yoshito Terai, Keisuke Ashihara, Satoe Fujiwara, Yoshimichi Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Masahide Ohmichi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5417643?pdf=render

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http://europepmc.org/articles/PMC5417643?pdf=render

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