The efficacy of the cyclin-dependent kinase 4/6 inhibitor in endometrial cancer.

The efficacy of the cyclin-dependent kinase 4/6 inhibitor in endometrial cancer.

BACKGROUND:PD-0332991, the selective cyclin-dependent kinase 4/6 inhibitor palbociclib, causes cell cycle arrest by inhibiting phosphorylation of retinoblastoma (Rb) protein. The aim of this study was to evaluate the therapeutic potential of PD-0332991 in endometrial cancer. METHODS AND FINDINGS:Fou...

Full description

Bibliographic Details
Main Authors:	Tomohito Tanaka, Yoshito Terai, Keisuke Ashihara, Satoe Fujiwara, Yoshimichi Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Masahide Ohmichi
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC5417643?pdf=render

Similar Items

A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma
by: Kazuya Maeda, et al.
Published: (2018-08-01)

GPR30 regulates the EGFR-Akt cascade and predicts lower survival in patients with ovarian cancer
by: Fujiwara Satoe, et al.
Published: (2012-11-01)

A rare case of ovarian carcinosarcoma with squamous cell carcinoma
by: Atsushi Daimon, et al.
Published: (2019-04-01)

Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary: a rare case report and review of the literature
by: Takai Masaaki, et al.
Published: (2012-12-01)

Laparoscopic Diagnosis of Adenocarcinoma of the Appendix Mimicking Serous Papillary Adenocarcinoma of the Peritoneum
by: Mayumi Yoshimura, et al.
Published: (2013-01-01)

Role of Cyclin-Dependent Kinase Inhibitors in Endometrial Cancer
by: Gaia Giannone, et al.
Published: (2019-05-01)

Recurrent ovarian cancer presenting in the right supraclavicular lymph node with isolated metastasis: a case report
by: Tanaka Tomohito, et al.
Published: (2012-07-01)

Cyclin-dependent kinase inhibitors: efficacy and safety
by: I. B. Kononenko, et al.
Published: (2019-06-01)

Serum exosomal microRNA-34a as a potential biomarker in epithelial ovarian cancer
by: Kazuya Maeda, et al.
Published: (2020-04-01)

The inhibitors of cyclin-dependent kinases and GSK-3β enhance osteoclastogenesis
by: Yosuke Akiba, et al.
Published: (2016-03-01)

PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY
by: E. V. Artamonova
Published: (2018-04-01)

A low-testosterone state associated with endometrioma leads to the apoptosis of granulosa cells.
by: Yoshihiro J Ono, et al.
Published: (2014-01-01)

Anti-angiogenic effects of Cyclin dependent kinase inhibitors
by: Liebl, Johanna
Published: (2008)

Isosteres of sulfonamide inhibitors of cyclin-dependent kinases (CDKs)
by: Henderson, Andrew
Published: (2005)

Inhibitors of Cyclin-Dependent Kinases: Types and Their Mechanism of Action
by: Paweł Łukasik, et al.
Published: (2021-03-01)

Safety and efficacy of cyclin-dependent kinase inhibitor rechallenge following ribociclib-induced limiting hypertransaminasemia
by: Jesús Fuentes-Antrás, et al.
Published: (2020-12-01)

Intraperitoneal cytology after laparoscopic radical hysterectomy with vaginal closure without the use of a manipulator for cervical cancer: a retrospective observational study
by: Tanaka T, et al.
Published: (2019-07-01)

Patient-Derived Xenograft Models in Cervical Cancer: A Systematic Review
by: Tomohito Tanaka, et al.
Published: (2021-08-01)

Purine Inhibitors of Cyclin-Dependent Kinase and Their Apoptosis and Cytotoxicity Mechanisms
by: M. Strnad, et al.
Published: (2001-01-01)

Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
by: Shaian Tavakolian, et al.
Published: (2020-05-01)

STRUCTURAL BIOINFORMATICS STUDY OF CYCLIN-DEPENDENT KINASES COMPLEXED WITH INHIBITORS
by: F. CANDURI, et al.
Published: (2018-05-01)

Cyclin-Dependent Kinase Inhibitors Induce Apoptosis in Plant Cells
by: M. Strnad, et al.
Published: (2001-01-01)

Cyclin-dependent kinase (CDK) 4/6 inhibitors in oncology
by: Karamitrousis Evangelos, et al.
Published: (2020-04-01)

Pelvic Abscess after Cesarean Section Treated with Laparoscopic Drainage
by: Yumi Murayama, et al.
Published: (2021-01-01)

Efficacy of cyclin dependent kinase 4 inhibitors as potent neuroprotective agents against insults relevant to Alzheimer's disease.
by: Priyankar Sanphui, et al.
Published: (2013-01-01)

Identification of novel inhibitors against Cyclin Dependent Kinase 9/Cyclin T1 complex as: Anti cancer agent
by: Afzal Hussain, et al.
Published: (2017-09-01)

The extent of cyclin D1 expression in endometrial pathologies and relevance of cyclin D1 with the clinicopathological features of endometrioid endometrial carcinoma
by: Hulya Tosun Yildirim, et al.
Published: (2020-01-01)

Cyclin-dependent kinase 7 inhibitor THZ1 in cancer therapy
by: Bin-Bin Li, et al.
Published: (2019-09-01)

Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy
by: Aisha Alsfouk
Published: (2021-01-01)

Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy
by: DePamphilis Melvin L, et al.
Published: (2009-06-01)

Efficient activation of reconstructed rat embryos by cyclin-dependent kinase inhibitors.
by: Robin L Webb, et al.
Published: (2010-03-01)

Structure-activity relationships for alkoxypirimidine inhibitors of cyclin-dependent kinases (CDK’s)
by: Marchetti, Francesco
Published: (2009)

Investigation of the molecular mechanism of action of novel cyclin-dependent kinase inhibitors
by: Barlow, Clare Stephanie
Published: (2009)

The design and synthesis of pyrimidine based cyclin-dependent kinase (CDK) inhibitors
by: Parsons, Rachel
Published: (2001)

Structure of the cyclin-dependent kinase inhibitor p19^INK⁴^d
by: Luh, Frederick Yatlin
Published: (1998)

Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3
by: Hare, Shannagh
Published: (2014)

Efficacy and Safety of Cyclin-Dependent Kinases 4 and 6 Inhibitors in HR+/HER2− Advanced Breast Cancer
by: Xie N, et al.
Published: (2020-06-01)

Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02
by: Caroline von Achenbach, et al.
Published: (2020-12-01)

Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs
by: Jennifer A. Cartwright, et al.
Published: (2019-02-01)

Computational approaches in the development of cyclin-dependent kinase 2 inhibitors for the treatment of cancer
by: Sykora, Vladimir
Published: (2009)