LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma

LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma

Oxidized LDL (oxLDL) promotes lipid accumulation as well as growth and survival signaling in macrophages. OxLDL uptake is mainly due to scavenger receptors SR-AI/II and CD36. However, other scavenger receptors such as lectin-like oxLDL receptor-1 (LOX-1) may also play a role. We used mice with targe...

Full description

Bibliographic Details
Main Authors: David F. Schaeffer, Maziar Riazy, Kuljit S. Parhar, Johnny H. Chen, Vincent Duronio, Tatsuya Sawamura, Urs P. Steinbrecher
Format: Article
Language:English
Published: Elsevier 2009-08-01
Series:Journal of Lipid Research
Subjects:
apoptosis
lysophosphatidycholine
macrophage
oxidized low density lipoprotein
scavenger receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520307689

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520307689

Similar Items