Muramyl dipeptide promotes Aβ1-42 oligomer production via the NOD2/p-p38 MAPK/BACE1 signaling pathway in the SH-SY5Y cells

Muramyl dipeptide promotes Aβ1-42 oligomer production via the NOD2/p-p38 MAPK/BACE1 signaling pathway in the SH-SY5Y cells

The relationship between chronic bacterial colonization in the brain and Alzheimer’s disease is attracting extensive attention. Recent studies indicated that the components of bacterial biofilm drive the amyloid-β production. Muramyl dipeptide, the minimal bioactive peptidoglycan motif common to all...

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Bibliographic Details
Main Author: Yan-Jie Chen, Yuan-Jin Chan, Wen-Jing Chen, Ya-Ming Li, Chun-Yan Zhang
Format: Article
Language:English
Published: IMR (Innovative Medical Research) Press Limited 2020-09-01
Series:Journal of Integrative Neuroscience
Subjects:
|alzheimer’s disease|muramyl dipeptide|nucleotide-binding oligomerization domain 2|β-site app cleaving enzyme 1|aβ1-42 oligomer
Online Access:https://jin.imrpress.com/fileup/1757-448X/PDF/1601430238448-990650090.pdf

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https://jin.imrpress.com/fileup/1757-448X/PDF/1601430238448-990650090.pdf

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