HIV-1 protease with leucine zipper fused at N-terminus exhibits enhanced linker amino acid-dependent activity

HIV-1 protease with leucine zipper fused at N-terminus exhibits enhanced linker amino acid-dependent activity

Abstract Background HIV-1 protease (PR) activation is triggered by Gag-Pol dimerization. Premature PR activation results in reduced virion yields due to enhanced Gag cleavage. A p6* transframe peptide located directly upstream of protease is believed to play a modulating role in PR activation. Previ...

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Bibliographic Details
Main Authors: Fu-Hsien Yu, Chin-Tien Wang
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Retrovirology
Subjects:
HIV-1
Gag-Pol
P6pol
Protease maturation
Virus maturation
Gag cleavage
Online Access:http://link.springer.com/article/10.1186/s12977-018-0413-6

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http://link.springer.com/article/10.1186/s12977-018-0413-6

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