Low-dose IL-34 has no effect on osteoclastogenesis but promotes osteogenesis of hBMSCs partly via activation of the PI3K/AKT and ERK signaling pathways

Low-dose IL-34 has no effect on osteoclastogenesis but promotes osteogenesis of hBMSCs partly via activation of the PI3K/AKT and ERK signaling pathways

Abstract Background Inflammatory microenvironment is significant to the differentiation and function of mesenchymal stem cells (MSCs). It evidentially influences the osteoblastogenesis of MSCs. IL-34, a newly discovered cytokine, playing a key role in metabolism. However, the research on its functio...

Full description

Bibliographic Details
Main Authors: Jianxiang Xu, Lifeng Fu, Jinwu Bai, Huiming Zhong, Zhihui Kuang, Chengwei Zhou, Bin Hu, Licheng Ni, Li Ying, Erman Chen, Wei Zhang, Jiaqi Wu, Deting Xue, Weixu Li, Zhijun Pan
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Low-dose IL-34
hBMSCs
mBMMs
Osteoblastogenesis
Osteoclastogenesis
Online Access:https://doi.org/10.1186/s13287-021-02263-3

Internet

https://doi.org/10.1186/s13287-021-02263-3

Similar Items