Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages

Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages

During the acute phase of Trypanosoma cruzi infection, macrophages can act as host cells for the parasites as well as effector cells in the early anti-parasitic immune response. Thus, the targeting of specific signaling pathways could modulate macrophages response to restrict parasite replication an...

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Bibliographic Details
Main Authors: Ximena Volpini, Laura F. Ambrosio, Laura Fozzatti, Constanza Insfran, Cinthia C. Stempin, Laura Cervi, Claudia Cristina Motran
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
Trypanosoma cruzi infection
Wnt proteins
beta-catenin
macrophages
cytokines
indoleamine 2,3-dioxygenase
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00859/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00859/full

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