High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model

High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model

Background: Graft versus host disease (GvHD) occurs in 20% of cases with patients having an MHC I matched bone marrow transplantation (BMT). Mechanisms causing this disease remain to be studied. Methods: Here we used a CD8+ T cell transgenic mouse line (P14/CD45.1+) and transgenic DEE mice bearing u...

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Bibliographic Details
Main Authors: Asmae Gassa, Halime Kalkavan, Fu Jian, Vikas Duhan, Vishal Khairnar, Namir Shaabani, Nadine Honke, Alexander Carpinteiro, Lacramioara Botezatu, Pietro Crivello, Sebastian Dolff, Stanislav Ferencik, Dieter Häussinger, Cyrus Khandanpour, Katharina Fleischhauer, Oliver Witzke, Thorsten Wahlers, Cornelia Hardt, Philipp A. Lang, Karl S. Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Bone Marrow Transplantation (BMT)
Minor Antigen Mismatch
Tolerance
Ignorance
LCMV
Mouse model
Online Access:http://www.karger.com/Article/FullText/443078

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http://www.karger.com/Article/FullText/443078

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