Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma

Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma

Abstract Background The development of novel and effective drugs for targeted human hepatocellular carcinoma still remains a great challenge. The alkaloid nitidine chloride (NC), a component of a traditional Chinese medicine, has been shown to have anticancer properties, but doses at therapeutic lev...

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Bibliographic Details
Main Authors: Danni Li, Shaogang Liu, Jiahao Zhu, Liqun Shen, Qi ying Zhang, Hua Zhu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Pharmacology and Toxicology
Subjects:
Nano-micelles
TPGS
Folic acid
Nitidine chloride
Anti-tumor activity
Huh7 human hepatocellular carcinoma line
Online Access:https://doi.org/10.1186/s40360-020-00461-y

Internet

https://doi.org/10.1186/s40360-020-00461-y

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