Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis

Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis

Human cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a pronounced inflammatory response associated with ulcer development. Monocytes/macrophages, the main cells harboring parasites, are largely responsible for parasite control. Toll-like receptor (TLR) signaling l...

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Bibliographic Details
Main Authors: Pedro Paulo Carneiro, Andreza S. Dórea, Walker N. Oliveira, Luiz Henrique Guimarães, Claúdia Brodskyn, Edgar M. Carvalho, Olívia Bacellar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
innate immunity
cytokines
cutaneous leishmaniasis
Leishmania braziliensis
toll-like receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.706510/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.706510/full

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