Specific metabolomics adaptations define a differential regional vulnerability in the adult human cerebral cortex

Specific metabolomics adaptations define a differential regional vulnerability in the adult human cerebral cortex

Brain neurons offer diverse responses to stresses and detrimental factors during development and aging, and as a result of both neurodegenerative and neuropsychiatric disorders. This multiplicity of responses can be ascribed to the great diversity among neuronal populations. Here we have determined...

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Bibliographic Details
Main Authors: Rosanna Cabré, Mariona Jové, Alba Naudí, Victoria Ayala, Gerard Piñol-Ripoll, Maria Pilar Gil-Villar, Mayelin Dominguez-Gonzalez, Èlia Obis, Rebeca Berdun, Natàlia Mota-Martorell, Manuel Portero-Otín, Isidre Ferrer, Reinald Pamplona
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Energy Metabolism
Metabolomics
Mitochondrial stress
selective neuronal vulnerability
nucleotide metabolism
mammalian target of rapamycin (mTOR)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00138/full

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http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00138/full

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