MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2

MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2

Abstract Background Morphine is widely used in clinical practice for a class of analgesic drugs, long-term use of morphine will cause the action of tolerance. MicroRNAs have been reported to be involved in morphine analgesic tolerance.. Methods Forty male SD rats were selected and randomly divided i...

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Bibliographic Details
Main Authors: Xian-Ping Wu, Rui-Xuan She, Yan-Ping Yang, Zu-Min Xing, Han-Wen Chen, Yi-Wen Zhang
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Biomedical Science
Subjects:
microRNA-365
β-arrestin2
Morphine tolerance
Extracellular signal-regulated kinase
cAMP-response element binding protein
Online Access:http://link.springer.com/article/10.1186/s12929-018-0405-9

Internet

http://link.springer.com/article/10.1186/s12929-018-0405-9

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