Hyaluronidase Inhibitory Activity of Pentacylic Triterpenoids from Prismatomeris tetrandra (Roxb.) K. Schum: Isolation, Synthesis and QSAR Study

Hyaluronidase Inhibitory Activity of Pentacylic Triterpenoids from Prismatomeris tetrandra (Roxb.) K. Schum: Isolation, Synthesis and QSAR Study

The mammalian hyaluronidase degrades hyaluronic acid by the cleavage of the β-1,4-glycosidic bond furnishing a tetrasaccharide molecule as the main product which is a highly angiogenic and potent inducer of inflammatory cytokines. Ursolic acid 1, isolated from Prismatomeris tetrandra, was identified...

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Bibliographic Details
Main Authors: Nor Hayati Abdullah, Noel Francis Thomas, Yasodha Sivasothy, Vannajan Sanghiran Lee, Sook Yee Liew, Ibrahim Ali Noorbatcha, Khalijah Awang
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:International Journal of Molecular Sciences
Subjects:
hyaluronidase
ursolic acid
QSAR
semi empirical quantum chemical
molecular docking
Prismatomeris tetrandra (Roxb.) K. Schum
Rubiaceae
Online Access:http://www.mdpi.com/1422-0067/17/2/143

Internet

http://www.mdpi.com/1422-0067/17/2/143

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