Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome.

Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome.

To identify molecular mechanisms underlying SCN5A-related sick sinus syndrome (SSS), a rare type of SSS, in parallel experiments we elucidated the electrophysiological properties and the cell surface localization of thirteen human Na(v)1.5 (hNa(v)1.5) mutant channels previously linked to this diseas...

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Bibliographic Details
Main Authors: Junhong Gui, Tao Wang, Richard P O Jones, Dorothy Trump, Thomas Zimmer, Ming Lei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2881866?pdf=render

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http://europepmc.org/articles/PMC2881866?pdf=render

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