Development of stable Vibrio cholerae O1 Hikojima type vaccine strains co-expressing the Inaba and Ogawa lipopolysaccharide antigens.

Development of stable Vibrio cholerae O1 Hikojima type vaccine strains co-expressing the Inaba and Ogawa lipopolysaccharide antigens.

We describe here the development of stable classical and El Tor V. cholerae O1 strains of the Hikojima serotype that co-express the Inaba and Ogawa antigens of O1 lipopolysaccharide (LPS). Mutation of the wbeT gene reduced LPS perosamine methylation and thereby gave only partial transformation into...

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Bibliographic Details
Main Authors: Stefan L Karlsson, Elisabeth Ax, Erik Nygren, Susanne Källgård, Margareta Blomquist, Annelie Ekman, John Benktander, Jan Holmgren, Michael Lebens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4232259?pdf=render

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http://europepmc.org/articles/PMC4232259?pdf=render

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