The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs

The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs

The affinity of cannabinoids for their CB<sub>1</sub> and CB<sub>2</sub> metabotropic receptors is dramatically affected by a combination of α-branching and elongation of their alkyl substituent, a maneuver exemplified by the <i>n</i>-pentyl -> α,α-dimethylhept...

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Bibliographic Details
Main Authors: Daiana Mattoteia, Aniello Schiano Moriello, Orazio Taglialatela-Scafati, Pietro Amodeo, Luciano De Petrocellis, Giovanni Appendino, Rosa Maria Vitale, Diego Caprioglio
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
phytocannabinoids
cannabichromene
thermos-TRPs
TRPA1
α,α-dimethylheptyl effect
Online Access:https://www.mdpi.com/2227-9059/9/8/1070

Internet

https://www.mdpi.com/2227-9059/9/8/1070

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