Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis

Abstract We measured plasma and cerebrospinal fluid (CSF) metabolite concentrations in a 5-day porcine sepsis model of fecal peritonitis. The objectives were: (i) to verify whether the expected pathways that had emerged in previous studies pertain only to the early inflammatory response or persist f...

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Bibliographic Details
Main Authors: Manuela Ferrario, Roberta Pastorelli, Laura Brunelli, Shengchen Liu, Pedro Paulo Zanella do Amaral Campos, Daniela Casoni, Werner J. Z’Graggen, Stephan M. Jakob
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97855-7