Chimeric HP-PRRSV2 containing an ORF2-6 consensus sequence induces antibodies with broadly neutralizing activity and confers cross protection against virulent NADC30-like isolate

Chimeric HP-PRRSV2 containing an ORF2-6 consensus sequence induces antibodies with broadly neutralizing activity and confers cross protection against virulent NADC30-like isolate

Abstract Due to the substantial genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV), commercial PRRS vaccines fail to provide sufficient cross protection. Previous studies have confirmed the existence of PRRSV broadly neutralizing antibodies (bnAbs). However, bnAbs are r...

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Bibliographic Details
Main Authors: Nanhua Chen, Shubin Li, Yunfei Tian, Xinshuai Li, Shuai Li, Jixiang Li, Ming Qiu, Zhe Sun, Yanzhao Xiao, Xilin Yan, Hong Lin, Xiuling Yu, Kegong Tian, Shaobin Shang, Jianzhong Zhu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Veterinary Research
Subjects:
PRRSV
Infectious clone
ORF2-6 consensus sequence
Broadly neutralizing antibodies
Cross protection
Genetic engineered vaccine
Online Access:https://doi.org/10.1186/s13567-021-00944-8

Internet

https://doi.org/10.1186/s13567-021-00944-8

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