Antisense Activity across the Nesp Promoter is Required for Nespas-Mediated Silencing in the Imprinted Gnas Cluster

Antisense Activity across the Nesp Promoter is Required for Nespas-Mediated Silencing in the Imprinted Gnas Cluster

Macro long non-coding RNAs (lncRNAs) play major roles in gene silencing in inprinted gene clusters. Within the imprinted Gnas cluster, the paternally expressed Nespas lncRNA downregulates its sense counterpart Nesp. To explore the mechanism of action of Nespas, we generated two new knock-in alleles...

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Bibliographic Details
Main Authors: Charlotte J. Tibbit, Christine M. Williamson, Stuti Mehta, Simon T. Ball, Mita Chotalia, Wade T. Nottingham, Sally A. Eaton, Mohamed M. Quwailid, Lydia Teboul, Gavin Kelsey, Jo Peters
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Non-Coding RNA
Subjects:
long non-coding RNA
antisense
genomic imprinting
epigenetic silencing
Nespas
Nesp
Gnas cluster
Online Access:http://www.mdpi.com/2311-553X/1/3/246

Internet

http://www.mdpi.com/2311-553X/1/3/246

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