Exploring the mode of action of bioactive compounds by microfluidic transcriptional profiling in mycobacteria.

Exploring the mode of action of bioactive compounds by microfluidic transcriptional profiling in mycobacteria.

Most candidate anti-bacterials are identified on the basis of their whole cell anti-bacterial activity. A critical bottleneck in the early discovery of novel anti-bacterials is tracking the structure activity relationship (SAR) of the novel compounds synthesized during the hit to lead and lead optim...

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Main Authors: Paul Murima, Paola Florez de Sessions, Vivian Lim, Ahmad Nazri Mohamed Naim, Pablo Bifani, Helena I M Boshoff, Vasan K Sambandamurthy, Thomas Dick, Martin L Hibberd, Mark Schreiber, Srinivasa P S Rao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3729944?pdf=render

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http://europepmc.org/articles/PMC3729944?pdf=render

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