Neurosteroid and benzodiazepine combination therapy reduces status epilepticus and long‐term effects of whole‐body sarin exposure in rats

Neurosteroid and benzodiazepine combination therapy reduces status epilepticus and long‐term effects of whole‐body sarin exposure in rats

Abstract Objective Our objective was to evaluate the protective efficacy of the neurosteroid pregnanolone (3α‐hydroxy‐5β pregnan‐20‐one), a GABAA receptor‐positive allosteric modulator, as an adjunct to benzodiazepine therapy against the chemical warfare nerve agent (CWNA) sarin (GB), using whole‐bo...

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Bibliographic Details
Main Authors: Lucille Lumley, Dennis Miller, William T. Muse, Brenda Marrero‐Rosado, Marcio de Araujo Furtado, Michael Stone, Jeffrey McGuire, Christopher Whalley
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Epilepsia Open
Subjects:
neurosteroids
benzodiazepine
chemical warfare nerve agent
refractory status epilepticus
thalamus
Online Access:https://doi.org/10.1002/epi4.12344

Internet

https://doi.org/10.1002/epi4.12344

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