Leukotriene B4-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression

Leukotriene B4-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression

Inflammation and infection are key promoters of colon cancer but the molecular interplay between these events is largely unknown. Mice deficient in leukotriene B4 receptor1 (BLT1) are protected in inflammatory disease models of arthritis, asthma and atherosclerosis. In this study, we show that BLT1−...

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Bibliographic Details
Main Authors: Venkatakrishna R. Jala, Paramahamsa Maturu, Sobha R. Bodduluri, Elangovan Krishnan, Steven Mathis, Krishnaprasad Subbarao, Min Wang, Alfred B. Jenson, Mary L. Proctor, Eric C. Rouchka, Rob Knight, Bodduluri Haribabu
Format: Article
Language:English
Published: Taylor & Francis Group 2017-12-01
Series:OncoImmunology
Subjects:
colon cancer
inflammation
blt1
chemokines
microbiota
myd88
host response
leukotriene b4
inflammation and cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1361593

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http://dx.doi.org/10.1080/2162402X.2017.1361593

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