The clinical significance of PD-L1 in advanced gastric cancer is dependent on ARID1A mutations and ATM expression

The clinical significance of PD-L1 in advanced gastric cancer is dependent on ARID1A mutations and ATM expression

Whether PD-L1 expression is associated with survival outcomes in gastric cancer (GC) is controversial. The inhibition of the PD-1/PD-L1 pathway is effective against genomically unstable tumors. Hypothesizing that also the clinical significance of PD-L1 might be dependent on the activation of molecul...

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Bibliographic Details
Main Authors: Simonetta Buglioni, Elisa Melucci, Francesca Sperati, Matteo Pallocca, Irene Terrenato, Francesca De Nicola, Frauke Goeman, Beatrice Casini, Carla Azzurra Amoreo, Enzo Gallo, Maria Grazia Diodoro, Edoardo Pescarmona, Patrizia Vici, Domenico Sergi, Laura Pizzuti, Luigi Di Lauro, Marco Mazzotta, Maddalena Barba, Maurizio Fanciulli, Ilio Vitale, Ruggero De Maria, Gennaro Ciliberto, Marcello Maugeri-Saccà
Format: Article
Language:English
Published: Taylor & Francis Group 2018-08-01
Series:OncoImmunology
Subjects:
gastric cancer
chemotherapy
pd-l1
dna damage repair
genomic stability
arid1a
atm
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1457602

Internet

http://dx.doi.org/10.1080/2162402X.2018.1457602

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