Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications

Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications

Diabetes mellitus is one of the major risk factors for cardiovascular disease and is an important health issue worldwide. Long-term diabetes causes endothelial dysfunction, which in turn leads to diabetic vascular complications. Endothelium-derived nitric oxide is a major vasodilator in large-size v...

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Bibliographic Details
Main Authors: Kenichi Goto, Takanari Kitazono
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
antidiabetic agent
Ca<sup>2+</sup>-activated K<sup>+</sup> channel
diabetes mellitus
endothelial function
endothelium-dependent hyperpolarization
endothelium-derived hyperpolarizing factor
gap junction
reactive oxygen species
Online Access:https://www.mdpi.com/1422-0067/20/15/3737

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https://www.mdpi.com/1422-0067/20/15/3737

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