Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications
Diabetes mellitus is one of the major risk factors for cardiovascular disease and is an important health issue worldwide. Long-term diabetes causes endothelial dysfunction, which in turn leads to diabetic vascular complications. Endothelium-derived nitric oxide is a major vasodilator in large-size v...
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doaj-42e3d068b7db4d9fbdd78fcbdae9629e2020-11-25T01:58:48ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-07-012015373710.3390/ijms20153737ijms20153737Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic ImplicationsKenichi Goto0Takanari Kitazono1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDiabetes mellitus is one of the major risk factors for cardiovascular disease and is an important health issue worldwide. Long-term diabetes causes endothelial dysfunction, which in turn leads to diabetic vascular complications. Endothelium-derived nitric oxide is a major vasodilator in large-size vessels, and the hyperpolarization of vascular smooth muscle cells mediated by the endothelium plays a central role in agonist-mediated and flow-mediated vasodilation in resistance-size vessels. Although the mechanisms underlying diabetic vascular complications are multifactorial and complex, impairment of endothelium-dependent hyperpolarization (EDH) of vascular smooth muscle cells would contribute at least partly to the initiation and progression of microvascular complications of diabetes. In this review, we present the current knowledge about the pathophysiology and underlying mechanisms of impaired EDH in diabetes in animals and humans. We also discuss potential therapeutic approaches aimed at the prevention and restoration of EDH in diabetes.https://www.mdpi.com/1422-0067/20/15/3737antidiabetic agentCa<sup>2+</sup>-activated K<sup>+</sup> channeldiabetes mellitusendothelial functionendothelium-dependent hyperpolarizationendothelium-derived hyperpolarizing factorgap junctionreactive oxygen species |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kenichi Goto Takanari Kitazono |
spellingShingle |
Kenichi Goto Takanari Kitazono Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications International Journal of Molecular Sciences antidiabetic agent Ca<sup>2+</sup>-activated K<sup>+</sup> channel diabetes mellitus endothelial function endothelium-dependent hyperpolarization endothelium-derived hyperpolarizing factor gap junction reactive oxygen species |
author_facet |
Kenichi Goto Takanari Kitazono |
author_sort |
Kenichi Goto |
title |
Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications |
title_short |
Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications |
title_full |
Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications |
title_fullStr |
Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications |
title_full_unstemmed |
Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications |
title_sort |
endothelium-dependent hyperpolarization (edh) in diabetes: mechanistic insights and therapeutic implications |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-07-01 |
description |
Diabetes mellitus is one of the major risk factors for cardiovascular disease and is an important health issue worldwide. Long-term diabetes causes endothelial dysfunction, which in turn leads to diabetic vascular complications. Endothelium-derived nitric oxide is a major vasodilator in large-size vessels, and the hyperpolarization of vascular smooth muscle cells mediated by the endothelium plays a central role in agonist-mediated and flow-mediated vasodilation in resistance-size vessels. Although the mechanisms underlying diabetic vascular complications are multifactorial and complex, impairment of endothelium-dependent hyperpolarization (EDH) of vascular smooth muscle cells would contribute at least partly to the initiation and progression of microvascular complications of diabetes. In this review, we present the current knowledge about the pathophysiology and underlying mechanisms of impaired EDH in diabetes in animals and humans. We also discuss potential therapeutic approaches aimed at the prevention and restoration of EDH in diabetes. |
topic |
antidiabetic agent Ca<sup>2+</sup>-activated K<sup>+</sup> channel diabetes mellitus endothelial function endothelium-dependent hyperpolarization endothelium-derived hyperpolarizing factor gap junction reactive oxygen species |
url |
https://www.mdpi.com/1422-0067/20/15/3737 |
work_keys_str_mv |
AT kenichigoto endotheliumdependenthyperpolarizationedhindiabetesmechanisticinsightsandtherapeuticimplications AT takanarikitazono endotheliumdependenthyperpolarizationedhindiabetesmechanisticinsightsandtherapeuticimplications |
_version_ |
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