Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus

Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus

Summary: In adult cornu ammonis hippocampi, erythropoietin (EPO) expression drives the differentiation of new neurons, independent of DNA synthesis, and increases dendritic spine density. This substantial brain hardware upgrade is part of a regulatory circle: during motor-cognitive challenge, neuron...

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Bibliographic Details
Main Authors: Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Yasmina Curto, Nadine Barnkothe, Imam Hassouna, Sebastian Jähne, Umer Javed Butt, Katharina Grewe, Martin S. Weber, Kim Green, Silvio Rizzoli, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreich
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
hypoxia
recombinant human EPO
neurogenesis
neurodifferentiation
CSF1R
IL-34
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009827

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http://www.sciencedirect.com/science/article/pii/S2211124721009827

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