Hyper-SUMOylation of ERG Is Essential for the Progression of Acute Myeloid Leukemia

Hyper-SUMOylation of ERG Is Essential for the Progression of Acute Myeloid Leukemia

Leukemia is a malignant disease of hematopoietic tissue characterized by the differentiation arrest and malignant proliferation of immature hematopoietic precursor cells in bone marrow. ERG (ETS-related gene) is an important member of the E26 transformation-specific (ETS) transcription factor family...

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Bibliographic Details
Main Authors: Xu Chen, Yuanyuan Qin, Zhenzhen Zhang, Zhengcao Xing, Qiqi Wang, Wenbin Lu, Hong Yuan, Congcong Du, Xinyi Yang, Yajie Shen, Biying Zhao, Huanjie Shao, Xiaotong Wang, Hongmei Wu, Yitao Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
ERG
SUMO2
SENP2
PML
AML
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.652284/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.652284/full

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