The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.

The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.

Conventional calpains are ubiquitous cysteine proteases whose activity is promoted by calcium signaling and specifically limited by calpastatin. Calpain expression has been shown to be increased in human malignant cells, but the contribution of the calpain/calpastatin system in tumorigenesis remains...

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Bibliographic Details
Main Authors: Quentin Raimbourg, Joëlle Perez, Sophie Vandermeersch, Aurélie Prignon, Guillaume Hanouna, Jean-Philippe Haymann, Laurent Baud, Emmanuel Letavernier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3614974?pdf=render

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http://europepmc.org/articles/PMC3614974?pdf=render

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