Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer

Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer

The long-term efficacy of the Epidermal Growth Factor Receptor (EGFR)-targeted antibody cetuximab in advanced colorectal cancer (CRC) patients is limited by the emergence of drug-resistant (persister) cells. Recent studies in other cancer types have shown that cells surviving initial treatment with...

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Bibliographic Details
Main Authors: Annalisa Lorenzato, Alessandro Magrì, Vittoria Matafora, Valentina Audrito, Pamela Arcella, Luca Lazzari, Monica Montone, Simona Lamba, Silvia Deaglio, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Angela Bachi, Federica Di Nicolantonio, Alberto Bardelli, Sabrina Arena
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
colorectal cancer
cetuximab
drug resistance
vitamin c
glucose metabolism
oxidative stress
ros
ferroptosis
Online Access:https://www.mdpi.com/2072-6694/12/3/685

Internet

https://www.mdpi.com/2072-6694/12/3/685

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