Circulating 4-F<sub>4t</sub>-Neuroprostane and 10-F<sub>4t</sub>-Neuroprostane Are Related to <i>MECP2</i> Gene Mutation and Natural History in Rett Syndrome

Circulating 4-F<sub>4t</sub>-Neuroprostane and 10-F<sub>4t</sub>-Neuroprostane Are Related to <i>MECP2</i> Gene Mutation and Natural History in Rett Syndrome

Neuroprostanes, a family of non-enzymatic metabolites of the docosahexaenoic acid, have been suggested as potential biomarkers for neurological diseases. Objective biological markers are strongly needed in Rett syndrome (RTT), which is a progressive X-linked neurodevelopmental disorder that is mainl...

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Bibliographic Details
Main Authors: Cinzia Signorini, Silvia Leoncini, Thierry Durand, Jean-Marie Galano, Alexandre Guy, Valérie Bultel-Poncé, Camille Oger, Jetty Chung-Yung Lee, Lucia Ciccoli, Joussef Hayek, Claudio De Felice
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
<i>MECP2</i> mutation
natural history
neurological disease
neuroprostanes
phenotype
Rett syndrome
Online Access:https://www.mdpi.com/1422-0067/22/8/4240

Internet

https://www.mdpi.com/1422-0067/22/8/4240

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