Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice

Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice

Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase enzyme with two isoforms (A1-cytosolic and A2-mitochondrial), is implicated in pathologies associated with obesity and diabetes. This...

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Bibliographic Details
Main Authors: Reem T. Atawia, Haroldo A. Toque, Mohamed M. Meghil, Tyler W. Benson, Nicole K. H. Yiew, Christopher W. Cutler, Neal L. Weintraub, Ruth B. Caldwell, Robert W. Caldwell
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
arginase
obesity
inflammation
metabolism
endothelial dysfunction
fatty acid oxidation
AMPK-α
Online Access:https://www.mdpi.com/1422-0067/20/6/1462

Internet

https://www.mdpi.com/1422-0067/20/6/1462

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