MicroRNA-mediated repression of nonsense mRNAs

MicroRNA-mediated repression of nonsense mRNAs

Numerous studies have established important roles for microRNAs (miRNAs) in regulating gene expression. Here, we report that miRNAs also serve as a surveillance system to repress the expression of nonsense mRNAs that may produce harmful truncated proteins. Upon recognition of the premature terminati...

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Bibliographic Details
Main Authors: Ya Zhao, Jimin Lin, Beiying Xu, Sida Hu, Xue Zhang, Ligang Wu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-08-01
Series:eLife
Subjects:
microRNA
nonsense mutation
nonsense-mediated mRNA decay
APC
intron retention
premature termination codon
Online Access:https://elifesciences.org/articles/03032

Internet

https://elifesciences.org/articles/03032

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