Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism.

Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism.

Here, we discovered an endogenous dafachronic acid (DA) in the socioeconomically important parasitic nematode Haemonchus contortus. We demonstrate that DA promotes larval exsheathment and development in this nematode via a relatively conserved nuclear hormone receptor (DAF-12). This stimulatory effe...

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Bibliographic Details
Main Authors: Guangxu Ma, Tao Wang, Pasi K Korhonen, Neil D Young, Shuai Nie, Ching-Seng Ang, Nicholas A Williamson, Gavin E Reid, Robin B Gasser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007960

Internet

https://doi.org/10.1371/journal.ppat.1007960

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