Modulation of Liver Inflammation and Fibrosis by Interleukin-37

Modulation of Liver Inflammation and Fibrosis by Interleukin-37

Background and Aims: Chronic inflammation induces liver fibrosis, cirrhosis and potentially liver cancer. Kupffer cells modulate hepatic stellate cells by secreting immunologically active proteins as TGF-β. TGF-β promotes liver fibrosis via the activation of Sma- and Mad-related protein 3. IL-37 bro...

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Bibliographic Details
Main Authors: Steffeni Mountford, Maria Effenberger, Heidi Noll-Puchta, Lucas Griessmair, Andrea Ringleb, Sonja Haas, Gerald Denk, Florian P. Reiter, Doris Mayr, Charles A. Dinarello, Herbert Tilg, Philip Bufler
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
TGF-β
Smad3
liver inflammation
serum levels
IL-37
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.603649/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.603649/full

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