Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population

Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population

Background: Lamotrigine (LTG) is commonly used for treatment of epilepsy and bipolar disorder. It is one of the common cause of cutaneous adverse drug reactions (CADR). Clinical symptoms of LTG-induced CADR range from maculopapular exanthema (MPE) to severe cutaneous adverse reactions (SCAR). This s...

Full description

Bibliographic Details
Main Authors: Napatrupron Koomdee, Jirawat Pratoomwun, Thawinee Jantararoungtong, Voralaksana Theeramoke, Wichittra Tassaneeyakul, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Siwalee Santon, Apichaya Puangpetch, Utcharee Intusoma, Therdpong Tempark, Tayard Deesudchit, Patompong Satapornpong, Anannit Visudtibhan, Chonlaphat Sukasem
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
lamotrigine
HLA-A
HLA-B
cutaneous adverse drug reactions
Thai population
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00879/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00879/full

Similar Items