Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

Aging is characterized by extensive metabolic reprogramming. To identify metabolic pathways associated with aging, we analyzed age-dependent changes in the metabolomes of long-lived Drosophila melanogaster. Among the metabolites that changed, levels of tyrosine were increased with age in long-lived...

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Bibliographic Details
Main Authors: Andrey A Parkhitko, Divya Ramesh, Lin Wang, Dmitry Leshchiner, Elizabeth Filine, Richard Binari, Abby L Olsen, John M Asara, Valentin Cracan, Joshua D Rabinowitz, Axel Brockmann, Norbert Perrimon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
tyrosine aminotransferase
TAT
tigecycline
mitochondria
neurotransmitters
ETC Complex I
Online Access:https://elifesciences.org/articles/58053

Internet

https://elifesciences.org/articles/58053

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