Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells

Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells

In the present study, the effect of cucurbitacin B (a natural product with anti-cancer effect) was studied on PC12 cells. It significantly reduced the cell number, changed cell morphology and inhibited colony formation while MTT results showed increased cell viability. Cucurbitacin B treatment incre...

Full description

Bibliographic Details
Main Authors: Chuanhong Wu, Jiaolin Bao, Chengwei He, Jinjian Lu, Xiuping Chen
Format: Article
Language:English
Published: Bangladesh Pharmacological Society 2015-12-01
Series:Bangladesh Journal of Pharmacology
Subjects:
Apoptosis
Autophagy
Cucurbitacin B
G2/M cycle
MTT
PC12 cell
Online Access:https://www.banglajol.info/index.php/BJP/article/view/23791

Internet

https://www.banglajol.info/index.php/BJP/article/view/23791

Similar Items