A novel method for detection of phosphorylation in single cells by surface enhanced Raman scattering (SERS) using composite organic-inorganic nanoparticles (COINs).

A novel method for detection of phosphorylation in single cells by surface enhanced Raman scattering (SERS) using composite organic-inorganic nanoparticles (COINs).

BACKGROUND:Detection of single cell epitopes has been a mainstay of immunophenotyping for over three decades, primarily using fluorescence techniques for quantitation. Fluorescence has broad overlapping spectra, limiting multiplexing abilities. METHODOLOGY/PRINCIPAL FINDINGS:To expand upon current d...

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Bibliographic Details
Main Authors: Catherine M Shachaf, Sailaja V Elchuri, Ai Leen Koh, Jing Zhu, Lienchi N Nguyen, Dennis J Mitchell, Jingwu Zhang, Kenneth B Swartz, Lei Sun, Selena Chan, Robert Sinclair, Garry P Nolan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2666268?pdf=render

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http://europepmc.org/articles/PMC2666268?pdf=render

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