A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy

A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy

Abstract Background Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder and is one of the most common muscular dystrophies. There are currently few effective therapies to treat the disease, although many small-molecule approaches are being pursued. Certain histone deacetylase inhibi...

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Bibliographic Details
Main Authors: Gist H. Farr, Melanie Morris, Arianna Gomez, Thao Pham, Elisabeth Kilroy, Elizabeth U. Parker, Shery Said, Clarissa Henry, Lisa Maves
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Skeletal Muscle
Subjects:
Chemical screen
Duchenne muscular dystrophy
Epigenetic small molecules
HDAC inhibitors
Zebrafish
Online Access:http://link.springer.com/article/10.1186/s13395-020-00251-4

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http://link.springer.com/article/10.1186/s13395-020-00251-4

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