AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone

Matrix-metalloproteinase-13 (MMP-13) has been shown to be an important protease in inflammatory and neoplastic conditions of the skeletal system. In particular, the stromal cells of giant cell tumor of bone (GCT) express very high levels of MMP-13 in response to the cytokine-rich environment of the...

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Bibliographic Details
Main Authors: Isabella W. Y. Mak, Robert E. Turcotte, Snezana Popovic, Gurmit Singh, Michelle Ghert
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Biochemistry Research International
Online Access:http://dx.doi.org/10.1155/2011/164197