KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways

KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways

The signaling cascades of the mitogen activated protein kinase (MAPK) family, calcineurin/NFATc4, and PI3K/Akt/GSK3, are believed to participate in endothelin-1 (ET-1)-induced cardiac hypertrophy. The aim of this study was to investigate whether KMUP-1, a synthetic xanthine-based derivative, prevent...

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Bibliographic Details
Main Authors: Shu-Fen Liou, Jong-Hau Hsu, You-Ting Chen, Ing-Jun Chen, Jwu-Lai Yeh
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
KMUP-1
endothelin-1
cardiac hypertrophy
reactive oxygen species
heme oxygenase-1
Online Access:http://www.mdpi.com/1420-3049/20/6/10435

Internet

http://www.mdpi.com/1420-3049/20/6/10435

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