Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.

Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.

Despite advances in the treatment of HIV infection with ART, elucidating strategies to overcome HIV persistence, including blockade of viral reservoir establishment, maintenance, and expansion, remains a challenge. T cell homeostasis is a major driver of HIV persistence. Cytokines involved in regula...

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Bibliographic Details
Main Authors: Christina Gavegnano, Jessica H Brehm, Franck P Dupuy, Aarthi Talla, Susan Pereira Ribeiro, Deanna A Kulpa, Cheryl Cameron, Stephanie Santos, Selwyn J Hurwitz, Vincent C Marconi, Jean-Pierre Routy, Laurent Sabbagh, Raymond F Schinazi, Rafick Pierre Sékaly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5739511?pdf=render

Internet

http://europepmc.org/articles/PMC5739511?pdf=render

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