SERPINE2 Inhibits IL-1α-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-κB/AP-1 Pathways.

SERPINE2 Inhibits IL-1α-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-κB/AP-1 Pathways.

Osteoarthritis (OA) is a chronic joint disease, characterized by a progressive loss of articular cartilage. During OA, proinflammatory cytokines, such as interleukin IL-1, induce the expression of matrix metalloproteinases (MMPs) in chondrocytes, contributing thus to the extracellular matrix (ECM) d...

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Bibliographic Details
Main Authors: Anna Santoro, Javier Conde, Morena Scotece, Vanessa Abella, Ana Lois, Veronica Lopez, Jesus Pino, Rodolfo Gomez, Juan J Gomez-Reino, Oreste Gualillo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4549255?pdf=render

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http://europepmc.org/articles/PMC4549255?pdf=render

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