Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women

Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women

Abstract Background Women have a higher risk of lethal arrhythmias than men in long QT syndrome type 2 (LQTS2), but the mechanisms remain uncertain due to the limited availability of healthy control human tissue. We have previously reported that in female rabbits, estrogen increases arrhythmia risk...

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Bibliographic Details
Main Authors: Rita Papp, Glenna C. L. Bett, Agnieszka Lis, Randall L. Rasmusson, István Baczkó, András Varró, Guy Salama
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Biology of Sex Differences
Subjects:
Sex differences in the human heart
Sex differences in arrhythmia phenotype
17-β-estradiol
L-type Ca2+ channel
Sodium-calcium exchanger
Regional heterogeneities in the heart
Online Access:http://link.springer.com/article/10.1186/s13293-017-0148-4

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http://link.springer.com/article/10.1186/s13293-017-0148-4

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