Immunohistochemical detection of p53 and pp53 Ser392 in canine hemangiomas and hemangiosarcomas located in the skin

Immunohistochemical detection of p53 and pp53 Ser392 in canine hemangiomas and hemangiosarcomas located in the skin

Abstract Background p53 protein is essential for the regulation of cell proliferation. Aberrant accumulation of it usually occurs in cutaneous malignancies. Mutant p53 is detected by immunohistochemistry because it is more stable than the wild-type p53. However, post-translational modifications of p...

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Bibliographic Details
Main Authors: María José García-Iglesias, Jose Luis Cuevas-Higuera, Ana Bastida-Sáenz, María Gracia de Garnica-García, Laura Polledo, Paula Perero, Jorge González-Fernández, Beatriz Fernández-Martínez, Claudia Pérez-Martínez
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Veterinary Research
Subjects:
Hemangiomas
Hemangiosarcomas
Skin
Dog
p53
Phospho-p53 Serine392
Online Access:http://link.springer.com/article/10.1186/s12917-020-02457-6

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http://link.springer.com/article/10.1186/s12917-020-02457-6

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