Amyotrophic Lateral Sclerosis-associated GGGGCC repeat expansion promotes Tau phosphorylation and toxicity

Amyotrophic Lateral Sclerosis-associated GGGGCC repeat expansion promotes Tau phosphorylation and toxicity

Microtubule-associated protein Tau (MAPT) and GGGGCC (G4C2) repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) are the major known genetic causes of frontotemporal dementia (FTD) and other neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS). Although expanded G4C2 r...

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Bibliographic Details
Main Authors: Hua He, Wen Huang, Ruoxi Wang, Yunting Lin, Yichen Guo, Jing Deng, Haitao Deng, Yanping Zhu, Emily G. Allen, Peng Jin, Ranhui Duan
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Drosophila
C9ORF72
G4C2 repeat expansion
Tau
ALS
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301482

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http://www.sciencedirect.com/science/article/pii/S0969996119301482

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